NTP Network Time Server DNTS-9 Application Cases · Beijing Zhongxinchuang Technology Co., Ltd. ( Neutron )

I. Company Profile of Ganlee Pharmaceutical Shandong Co., Ltd.

Ganlee Pharmaceutical Shandong Co., Ltd. was established in 2019 Year 10  Month, located in the Economic Development Zone of Linyi City, Shandong Province, with a registered capital of 2.3  RMB 100 million, is Ganlee Pharmaceutical Co., Ltd. (stock code: 603087.SH It is a wholly owned subsidiary and an important pharmaceutical production base under Ganlee Pharmaceutical’s internationalization and industrialization strategy. The company focuses on the manufacturing of biologics, medical devices, and chemical drugs, with a product portfolio that includes insulin and other antidiabetic medications, serving both domestic and international markets.

The base is located at 2020 Year 6  Construction will commence in [month], with Phase I investment of approximately [amount]. 27  hundred million yuan, covering an area of approximately 480  mu, with a total building area of approximately 27  Covering an area of 10,000 square meters, the facility includes biopharmaceutical, chemical pharmaceutical, and medical device production workshops, along with supporting infrastructure. The company has obtained certifications for its quality management system, environmental management system, occupational health and safety management system, and energy management system, and holds relevant licenses such as the Pharmaceutical Production License and the Medical Device Production License. It has also been recognized as a specialized, refined, distinctive, and innovative small and medium-sized enterprise.

As GMP Under regulatory requirements, biopharmaceutical companies operate a wide array of information systems covering production control, batch record‑keeping, quality testing and inspection, warehousing and logistics, as well as security and operations maintenance. These systems impose stringent requirements for clock synchronization across all networked devices and systems, the accuracy of event timestamps, and the traceability of data records.

II. Customer Requirements

In conjunction with the pharmaceutical manufacturing industry GMP Quality Management and Data Integrity ( Data Integrity ) Requirements: During the project construction, the client has put forward the following time-synchronization-related requirements:

• Unified Standard Time: For Production Automation ( DCS/SCADA/BMS ), GMP Informationization ( MES Batch records), laboratory ( LIMS/CDS ）、provides a consistent, traceable Beijing Time reference for systems such as warehousing and environmental monitoring, corporate office operations, and security and fire protection;
• Synchronization accuracy requirements: Achieve time synchronization accuracy within milliseconds across a large number of servers, data acquisition terminals, and control devices, ensuring the integrity of electronic batch records and audit trails. Audit Trail ) the accuracy and consistency of timestamps;
• Multi-source redundancy and reliability: supports BeiDou. /GPS By integrating satellite time synchronization with terrestrial time sources, the system relies on a local timing unit to provide stable timekeeping even during satellite signal anomalies or brief outages, ensuring uninterrupted time‑service delivery in continuous production environments.
• Security and Compliance: Supports identity authentication, access control, and encrypted transmission; time‑stamped logs are fully traceable, meeting the management requirements for information system audits and data provenance in pharmaceutical enterprises.
• Centralized management: Provides unified monitoring of time source operational status, client synchronization deviations, and alerts, thereby reducing operational and maintenance costs.
• Seamless scalability: Supports future workshop expansion and multi-level time-source cascading, meeting the needs of subsequent production-line construction and system scaling at the site.

III. Procured Products ( DNTS-9 Technical specifications)

The core product procured and deployed for this project is independently developed by Beijing Zhongxinchuang Technology Co., Ltd. DNTS-9 All-round type NTP Network time server. This product is for… 19  inch 1U Standard rack-mounted equipment, employing x86 Server Platform and Full Features Linux Server Operating system, supports multiple modes. GNSS Satellite time synchronization, multiple terrestrial time source inputs, and local timekeeping enable it to serve as a primary time source for pharmaceutical enterprise networks. Stratum 1 ) Use.

Note: The above technical specifications are compiled from the official website of Beijing Zhongxinchuang Technology Co., Ltd. ( www.neutrontek.com ) Product information is publicly available; the actual specifications of the delivered equipment shall prevail.

Figure 2　 DNTS-9 All-round type NTP Schematic Diagram of Network Time Server Device Interfaces and Status Indicators (Diagram, not an actual photograph)

IV. Solution

• Core time source deployment: Deployed in the production center’s data center. DNTS-9 All-round type NTP The time server, serving as a primary time source, is connected to the equipment installed on the factory roof. GNSS Satellite receiving antenna, with long-term tracking of the BeiDou system, GPS and multi-system satellite signals;
• Multi-source redundancy and timing assurance: Configured with multi-mode. GNSS The receivers are mutually redundant and can be connected to. IRIG-B、 1PPS+ToD , superior NTP It uses a ground-based time source and is equipped with a temperature-compensated crystal oscillator (with an optional rubidium atomic clock) as its local timing reference. When satellite signals are unavailable, it leverages all-digital phase-locked loop technology to maintain time accuracy, ensuring that time-source switching remains transparent to user terminals.
• Network-wide time distribution: via the plant’s core and aggregation switches to production automation, MES Electronic batch records, LIMS Laboratory, warehousing, and environmental monitoring, ERP/OA , to integrate video surveillance and energy metering systems, among others NTP Time distribution, achieving a unified time reference across the entire plant;
• Centralized Monitoring and Alerting: Deployed as a Complementary Solution DNTS Manager Centralized Monitoring Platform ( B/S architecture), it provides unified monitoring of the time source status, client‑side synchronization offset, and synchronization link latency; in case of anomalies, it… SNMP Trap 、 Syslog And dry-contact alarms promptly notify operations and maintenance personnel;
• Safety and Traceability: Enabled MD5/SHA Authentication, user identity verification, and hierarchical access control, along with the complete retention of time-stamped logs, ensure compliance with… GMP Auditing of time and data provenance is required under data integrity requirements.

Figure 3 　Schematic Diagram of Multi-Time-Source Priority Switching and Timing Assurance Mechanism

V. Implementation Results

• Production control, batch records, quality inspection, warehousing, office operations, and security systems are all synchronized to a unified time source, with terminal time deviations consistently maintained within the millisecond range.
• The consistency of timestamps across electronic batch records, test data, and system logs has been improved, providing… GMP Audit Trails and Data Reliability ( ALCOA+ Principle: Provide temporal support;
• With dual redundancy provided by satellite time synchronization and local timekeeping, the equipment can continue to deliver continuous, stable timing services even under conditions of weak satellite signals or brief signal interruptions, thereby meeting the requirements of uninterrupted production.
• Through DNTS Manager The centralized monitoring platform provides visualized management of device operating status, client synchronization status, and anomaly alerts, thereby reducing the operational and maintenance burden on the IT and automation departments.
• Logs are traceable, and access permissions are controllable, providing support for the company’s quality management, information system auditing, and data traceability.

Figure 1 　Schematic Diagram of the Unified Clock Synchronization System Deployment for Ganlee Pharmaceutical Shandong Co., Ltd. (Diagrammatic illustration; not an actual photograph)

VI. Typical Application Cases (Healthcare and Key Industries)

The choice of numerous departments and enterprises reflects recognition of Zhongxin Chuang’s products and services. Beyond the healthcare sector, Beijing Zhongxin Chuang… NTP / Clock server products are also widely deployed across key industries and sectors, including telecommunications, power, finance, scientific research, government, transportation, energy, and manufacturing. Relevant user organizations include (in no particular order):

Shenzhen: Huawei, ZTE, Datang, Honeywell (China), Yokogawa Electric (China), Emerson (China) Motors, Nokia, Siemens (China), ABB China, Schneider Electric (China), Baidu, Alibaba Cloud, Tencent Cloud, Zhejiang Dahua Group, Sail Network, Beijing Banknote Printing, Jinnan Data Lake, Visionox, Qingdao Hisense Network, Fujian Newland Software Engineering, Beijing HuaSheng TianCheng, Fujian Rongji Software Co., Ltd., Shanghai Baoxin Software Co., Ltd., Shanghai Tianbai Broadband Network, China National Tobacco (Yunnan) Reconstituted Tobacco, Chongqing Cigarette Factory, Shengle Industrial Park, Beijing Shouchuang Environmental Protection Group, BOE, Lenzing (Nanjing) Fibers, Digital China (China), Tsinghua Unigroup, Shanghai Bell, Taiwan’s Formosa Plastics, Weihai Triangle Tire, Henan Huayuan Photovoltaic, Jiaxing Duoneng Automation Equipment, Tangshan Sanyou Chlor-Alkali Company, Inner Mongolia Desheng Blast Furnace Overhaul Project, Winosin, Shanghai Tieda Telecom, Nanjing EnruiTe Industrial, Jinchang Construction, AVIC Engineering Integrated Equipment, Hangzhou Enhé Bio, Shandong Fangxin Network, Beijing Xuedilong, Lunan Pharmaceutical Group, Guangzhou Jianxin, Tianyi Cloud, SMIC South, Jiaxing Huashu, Chengdu Guowei Biopharmaceutical, Aerospace. 8  Institute, Sichuan Guowei Pharmaceutical, Dongying Yellow River Delta Digital Exhibition Hall Project, Rockwell, Xiaoshan ENN Smart Operations Center, Erxianmiao Security Project, France SPL Cement project, FAW Dongji Gong shock absorbers, Shanghai SMIC Oriental, Emerson Process Control, Adisseo Nanjing, Chongqing Lottery, INEOS Styrenics polymer materials (Ningbo), Jiangsu Shituo, Juguang Technology, Guangzhou Cigarette Factory, Chongqing Xingwang, Nanjing Enruite, Beijing Mining and Metallurgy Science & Technology Group, Digital Ningxia construction and operations, Xinxu Group, Xinjiang Xinye, BOE Huacan Optoelectronics Zhejiang, Hangzhou Holley Automation, Beijing Tiantan Biological Products, China United Network Communications Pingdingshan Branch, Laos. BRT Shandong Qisheng Industry and Trade Co., Ltd., Zhuzhou CRRC Semiconductor, Anhui Huasu Co., Ltd., Fujian Haiquan Chemical, Chongqing BOE Optoelectronics Technology, ASE Enterprise Services (Shanghai), SMIC, and others.

VII. Conclusion

The choice of numerous departments and enterprises signifies recognition of Zhongxinchuang’s products and services. Beijing Zhongxinchuang Technology Co., Ltd. will continue to uphold “ Innovative technology, serving a better life. ” the company’s mission, with “ Becoming a creator of premium quality. ” With this goal in mind, we will work in close collaboration with partners from all sectors to jointly achieve win-win outcomes and shared progress for both our enterprise and society.

VIII. Regarding Beijing Zhongxinchuang Technology Co., Ltd.

Beijing Zhongxinchuang Technology Co., Ltd. was established in 2002 In [year], located adjacent to Beijing’s Zhongguancun Software Park, the company was among the first in China to research and manufacture time servers and other intelligent network products, and it possesses… ISO9001 It has obtained quality management system certification and has accumulated test reports and certification certificates issued by specialized institutions such as the National Institute of Metrology and the National Time Service Center.

The company remains committed to the research and development, manufacturing, sales, and service of time‑frequency products. NTP/SNTP Server, PTP-IEEE1588 Master clock, GPS/ Beidou time and frequency synchronization products, digital master‑slave clocks, satellite‑based spatiotemporal security isolation devices, and other offerings span multiple product series and dozens of models, finding widespread application across critical sectors and domains, including government agencies, public security and judicial bodies, research institutes, the financial and insurance industries, healthcare and broadcasting, power and telecommunications, education and academia, the petrochemical and steel industries, defense forces, and railway transportation.

Official website: https://www.neutrontek.com

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